Human Stem Cell Derived Growth Factors work like Magic!
Stem Cells and Skincare
For years I have been fascinated by the burgeoning research of the human genome project, epigenetics, neuroplasticity, and most importantly for the purposes of todays article, stem cells and skincare sciences. Years working in anti-aging have brought me to question aging and longevity on a multitude of dimensions. As a society battling disease, dysfunction and disability, the breakthroughs in anti-aging are extremely promising in terms of improving length and quality of life and are bringing us closer to the ever so elusive ‘Fountain of Youth’.
Studies have shown that the human lifespan has a biological age limit that is governed by cellular and mitochondrial health. Specifically, our biological age is strongly correlated with the length of telomeres located at the ends or our chromosomes which shorten as we get older. One theoretical study estimates that our biological age limit can potentially reach up to 104 years; historical records, however, can confirm that at least one woman lived up to 122 years and several others have reached 120 years.
At the other end of the scientific spectrum another school of thought led by well-known futurists, Ray Kurzweil (American inventor and futurist that predicted the internet, and co-founder of the Singularity University), and Peter Diamandis (NYT bestselling author, founder of the X Prize Foundation, and co-founder of the Singularity University) believe in a theory called ‘longevity escape velocity’. This theory posits that advances in sciences will reach a point in time, where for every year that we age, advanced life-extension technologies will be able to give us back more than a year in life. I love and respect both of these positions on longevity — one for the fundamental science and research supporting it; and the other for the sheer enormity and audacity of dreaming BIG. However, this article is about human stem cell sciences, the growth factors that they generate, and how they can help regenerate skin and improve wound healing.
More than just length of life, I believe in a high quality of life in every possible dimension, and the skin is an important organ and the front line of our body’s defenses constantly under stress, one we as society are only now beginning to take better care of thanks to better awareness.
Growth Factor Experiment
I want to share with you an experiment that I conducted on myself when I used some advanced growth factor products following an at-home mishap that occurred while trying to remove a skin blemish above my forehead . I took pictures as I used a protocol involving the application of Growth Factors derived from Human Bone Marrow (Mesenchymal Stem Cells) with a new at home beauty tool prototype which boosts product absorption 20 times more than the skin’s normal absorption rate (see video below.) .
Original Link: https://www.youtube.com/watch?v=_2e54XRUedg
Stem Cell Basics
Before I get into the before and afters, I want to cover some basics of stem cell sciences and human growth factors because they are different with respect to how they engage the cells in our bodies. For the sake of today’s discussion, I will cover the 2 types of human stem cells, i.e., embryonic stem cells and adult stem cells with a larger focus on adult or ‘somatic’ stem cells.
Stem cells can develop into many different cell types in the body during early growth and development. In many tissues, they serve as an internal repair system in which they divide without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential to remain a stem cell or to become another type of cell with a more specialized function, such as a muscle, red blood, or brain cell to name few. Stem cell research continues to advance our understanding of how organisms develop from a single cell; and how healthy cells replace damaged cells in adult organisms. Stem cell research is one of the most fascinating areas of contemporary biology, but, as with many other expanding fields of scientific inquiry, research on stem cells raises scientific questions as rapidly as it generates new discoveries.[1. NIH Stem Cell Information site https://stemcells.nih.gov/sites/default/files/SCprimer2009.pdf]
Stem cells are extracted and stabilized ex vivo (outside of the human body) in a laboratory and then cultivated and maintained to release a variety of human growth factors (hundreds of different growth factor types have been discovered). The growth factors are stabilized by placing them into a medium (usually encapsulated in a lipid/fatty acid for delivery purposes) and finally added to a topical serum. Many of these serums will also have additional ingredients like powerful anti-oxidants and amino acids that are fundamental to cellular renewal and health. In skincare, adipose and mesenchymal stem cell-derived growth factors are the most common when dealing with human sources as opposed to animal, plant, or marine variations of stem cells and growth factors that can be commonly found in serums.
Stem Cells and their corresponding Growth factors
Adipose stem cells are extracted from human fat. All body fat contain adipose stem cells that create a variety of growth factors that are employed by our body’s immune system in various capacities. Since adipose stem cells tend to have inflammatory properties, it is believed that growth factors derived from adipose stem cells can cause inflammation and lessen the net positive effect. These stem cells are typically harvested from donated fat obtained from liposuction procedures.
Mesenchymal Stem Cells are extracted from the body’s bone marrow. These stem cells have actually shown some of the highest quality results when used to repair cardiac tissue (post heart surgery) or damage resulting from heart attacks. Its positive impact in burn victims and other severe dermal and epidermal damage has also been noted in numerous trials and studies. Due to its low inflammatory properties in comparison to adipose stem cells, bone marrow stem cells and their growth factors tend to deliver a more consistent and positive result based on my experience and the research I have studied.
Blood Stem Cells derived from placing freshly extracted blood into a centrifuge in order to isolate the Platelet Rich Plasma (PRP). It is currently used in autologous (obtained from the same individual) procedures, such as the popular micro-needling alternative, the Vampire Facial, as well as in the PRP injections made popular by Kim Kardashian and other celebrities looking to stimulate the body’s creation of collagen and elastin, i.e., the key building blocks to healthy and long-lasting skin.
Now back to my experiment. I had been using a potent formulation of mesenchymal growth factors to repair a wound resulting from a blemish on my forehead. Once it was finally extracted, there was a lot of damage to the epidermis. I began applying the growth serum directly onto the wounded skin and then used the at-home Nano Pen tool developed with nanotechnology to help safely infuse the serum.
After a few days, a new layer of epidermis formed. I used the tool 2 times over a period of 7 days and managed to document most of it. See some of the pictures below documenting the progression of my wound healing. I have also included a video to show how the Nano Pen delivered the product with accelerated absorption and aided in the body’s natural regenerative processes without creating unnecessary inflammation or downtime.
I have been amazed by some of the results arising from several growth factor products that I have had the luxury and honor of testing. I am in awe of the advances we have achieved in the formulation of anti-aging and wound healing products. Science and technology have begun to tap into the ability to beneficially transform the human body along the physical, biological and metaphysical planes. For many years, I had maintained a very dubious stance to anyone claiming to have found the “Fountain of Youth” and the cries of hucksters who will “turn back the clock” while using temporary paralyzers and short-term fixes.
Prior to conducting this experiment I was feeling dubious about the claims of some of the products I was asked to test, however, I was reminded by a close friend and wise soul of a profound quote that stuck with me:
“There are only two ways to live your life. One is as though nothing is a miracle. The other is as though everything is a miracle.” ― Albert Einstein
The results I was able to achieve in such a short time frame during my experiment, especially when considering the extent of the damage my skin had undergone, are nothing short of miraculous. I can say with confidence that the advances coming down the pike in skincare, and stem cell sciences as a whole, are nothing shy of pure magic.
1ST DAY USING SERUM AND NANO PEN 9/05/2018.
DAILY USE OF GROWTH FACTOR SERUM FROM 9/05 TO 9/11/2018.
2ND USE OF NANO PEN AND GF SERUM 9/09/2018.
FINAL PHOTOS 9/11/2018
Also published on Medium here: https://medium.com/@davidlozovsky/stem-cells-and-skincare-75cb4b681529